Historical clue formulations

• What Excedrin relieves — 2026-02-08
• Cause of a grimace — 2024-12-31
• Total headache — 2024-08-18
• Total hassle — 2024-01-25
• Major inconvenience — 2023-09-17
• Nuisance — 2023-09-13
• French bread — 2023-09-03
• Bother — 2023-05-28
• Big nuisance — 2023-03-27
• Hassle — 2022-06-16
• Bread: Fr. — 2022-04-20
• Bother — 2021-12-22
• Something necessary for gain, they say — 2021-12-05
• Royal ___ — 2021-10-16
• Total inconvenience — 2020-11-13
• Pill ... or a reason to take a pill — 2020-09-15
• Bother — 2020-06-09
• Masochist's pleasure — 2020-04-05
• Tylenol target — 2019-07-08
• Tough person to tolerate — 2018-02-01
• Big nuisance — 2017-09-26
• Nuisance — 2017-08-04
• Suffering — 2015-12-29
• Hassle — 2014-11-21
• Pest — 2014-08-17
• Distress — 2013-12-08
• Ibuprofen target — 2013-07-02
• What a dolorimeter measures — 2013-02-01
• Ache — 2013-01-07
• It may be unbearable — 2012-05-26
• Ache — 2012-04-23
• Sibling, at times? — 2012-01-06
• Nuisance — 2011-06-04
• Hassle — 2011-05-22
• What lines with stars at the end indicate in comics — 2010-11-23
• Pest — 2010-03-28
• Analgesic's target — 2009-10-14
• Aspirin target — 2009-08-24
• Cause of a wince — 2008-09-10
• Pest — 2008-07-30
• Nuisance — 2008-05-14
• Pill — 2007-09-23
• Result of punishment — 2007-09-06
• Ibuprofen target — 2007-04-24
• Baby brother, often — 2007-03-31
• Number's target? — 2006-06-11
• Feeling that makes you say "Ow!" — 2006-01-02
• Cause of a wince — 2005-05-24
• Bother — 2005-02-06
• What an analgesic stops — 2004-09-07