"The origin of wisdom," per René Descartes Crossword Clue

• Reservations

  New York Times · Thursday, June 11, 2026 · 5 letters

• "No ___!"

  New York Times · Wednesday, December 10, 2025 · 5 letters

• "When in ___, don't" (maxim attributed to Benjamin Franklin)

  New York Times · Friday, June 30, 2023 · 5 letters

• Impostor syndrome feeling

  New York Times · Thursday, April 7, 2022 · 5 letters

• Reservation

  New York Times · Friday, May 29, 2020 · 5 letters

• Call into question

  New York Times · Sunday, June 30, 2019 · 5 letters

• Uncertainty

  New York Times · Sunday, July 22, 2018 · 5 letters

• "But what if I'm wrong?" feeling

  New York Times · Monday, August 21, 2017 · 5 letters

• It may be reasonable to a jury

  New York Times · Monday, March 20, 2017 · 5 letters

• "When in ___, tell the truth": Mark Twain

  New York Times · Sunday, December 20, 2015 · 5 letters

More clues from this crossword

• 44-Across Remington of 1980s TV
• 45-Across Actor Fitch of "This Is Us"
• 46-Down ___ Peninsula (Horn of Africa)
• 47-Across As yet
• 48-Down Rabbit ___
• 49-Across Parts of LEDs
• 51-Down Follow
• 52-Down Asparagus, essentially
• 53-Across Berkeley, familiarly
• 53-Down "See ya!"
• 54-Across In working order
• 55-Down Eject