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Vicissitudes of life, as for the inventor named in the circled squares? Crossword Clue

11 letters · New York Times · Wednesday, March 27, 2013 · 25-Down

Appeared in 1 New York Times Crossword: Wednesday, March 27, 2013.

Exact puzzle match · New York Times · March 27, 2013 · 25-Down · 11 letters

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What does this clue mean?

Periods of positive and negative events, moods, or interactions; highs and lows.

noun

WordNet® (Princeton University)

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